Endocrine Abstracts

Aim: To compare influence of transdermal versus peroral estrogen treatment on insulin sensitivity, lipid and hormonal levels in women affected with polycystic ovary syndrome (PCOS).Patients and Methods: 17 women with PCOS, age 24.8 (4.2) years, BMI 24.15 (3.68) were randomly assigned either for peroral (8) or transdermal (9 patients) estrogens in conjunction with cyproteronacetate. In the early follicular phase of menstrual cycle before and then after 3 month of treatment ...

The influence of the hypothyroidism (H) on the glucose metabolism (GM) has not been studied by modern methods till now. We described the changes in the effect of insulin on GM in patients in artificial H and after the thyroid hormone therapy (T).Materials and Methods: We have investigated 15 female patients (age 32.8 plus/minus 8.1 years) in H (ssTSH 84.45 plus/minus 19.69 milli international units per litre; fT4 1.68 plus/minus 0.77 picomoles per litre;...

Introduction: The SNP rs7578597 (Thr1187Ala) of THADA gene was identified in GWA studies as a novel type 2 diabetes risk locus. Nevertheless, subsequent studies of this SNP effect have been inconclusive. In some studies, rs7578597 has been associated with insulin secretion but no significant correlation with type 2 diabetes has been reported. Product of THADA gene is considered to be involved in apoptosis. Whether rs7578597 affects insulin secretion throught the apoptosis of p...

The polycystic ovary syndrome (PCOS) is associated with features of the insulin resistance syndrome and altered glucose homeostasis. Factors that play an important role in these processes are still emerging. Adipokines and pro-inflammatory cytokines may be involved in development of insulin resistance in PCOS. The purpose of this study was to determine if a relationship exists between adiponectin, resistin, leptin, interleukin (IL) 4, IL6, IL10, tumor necrosis factor α (T...

The relationship of insulin resistance, androgens and endothelial dysfunction in polycystic ovary syndrome ,PCOS, is controversial till now. We evaluated if ICAM-1 levels differ between PCOS and healthy women and whether this marker of the early endothelial damage is associated with the particular metabolic and/or hormonal characteristics.After signing written informed consent, 39 PCOS women -median of age 25 yrs, BMI 24.9 and 10 age matched healthy wome...

The A-3826G gene polymorphism of the uncoupling protein 1 (UCP1) causes the lower expression of UCP1 in visceral fat and reduced energy expenditure. Peroxisome proliferator activated receptor gamma 2 (PPARG2) plays a role in the regulation of the adipocyte differentiation and energy balance. The Pro12Ala polymorphism is associated with better insulin sensitivity. We compare the genotypic distribution of these polymorphisms in PCOS and controls and study their possible associat...

Introduction: Bariatric surgery has been proved to be the most effective treatment for type 2 diabetes mellitus (T2D). Post-operative improvement in insulin sensitivity seems to be partly independent of weight loss and may be affected by changes in incretin secretion. Previous studies reported that the glucose-dependent insulinotropic polypeptide (GIP)-induced enhancement of fat stores may lead to increased insulin resistance. We determinated the effect of laparoscopic adjusta...